Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

CAS：25122-46-7
中文别名：氯倍氟美松丙醋酸;21-氯-9α-氟-11β,17α-二羟基-16β-甲基-1,4-妊娠双烯-3,20-二酮-17-丙酸酯;特美肤;17-丙酸氯倍他索;氯倍他索丙酸酯;
英文别名：cgp9555;CCl 4725;GR-2/92;Clobetasol propionate;clobetasol-17-propionate;Olux;Dermoval;21-Chloro-9α-fluoro-11β,17α-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-Propionate;Clobetasol 17-Propionate;GR 2/925;clobesol;Psorex;Dermovate;Cloβsol 17-Propionate;Clobetasolpropionate;Temovate;
分子式：C25H32ClFO5
分子量：466.97
精确质量：466.192
Psa：80.67
Logp：4.1031

MDL号：MFCD00058499
PubChem号：24893013
EINECS号：246-634-3

外观与性状：白色结晶粉末
密度：1.28 g/cm3
沸点：569ºC at 760 mmHg
熔点：195.5-197ºC
闪点：297.9ºC
折射率：1.56
储存条件：库房通风低温干燥
蒸汽压：2.58E-15mmHg at 25°C

安全说明：S26-S36
危险类别码：R36/37/38
海关编码：2937290090
危险品标志：Xi

用途
丙酸氯倍他索为人工合成的高效局部外用糖皮质激素类药物。具有较强的抗炎、抗瘙痒和毛细血管收缩作用，其抗炎作用约为氢化可的松的112.5倍，倍他米松磷酸钠的2.3倍，氟轻松的18.7倍。同时具有抑制细胞有丝分裂的作用，能有效地渗透进皮肤角质层。