化学科研者一站式服务平台
-
非马沙坦
2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
化合物简介
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea in September 9, 2010 and is available under the brand name Kanarb through Boryung Pharmaceuticals, who are presently seeking worldwide partnership.
基本信息
CAS：247257-48-3
中文别名：2-丁基-5-二甲基氨基硫代甲酰甲基-6-甲基-3-[[2\'-(1H-四唑-5-基)联苯-4-基]甲基]嘧啶-4(3H)-酮;
英文别名：FIMASARTAN;BR-A-657K;
分子式：C27H31N7OS
分子量：501.646
精确质量：501.231
Psa：124.68
Logp：4.2212
中文别名：2-丁基-5-二甲基氨基硫代甲酰甲基-6-甲基-3-[[2\'-(1H-四唑-5-基)联苯-4-基]甲基]嘧啶-4(3H)-酮;
英文别名：FIMASARTAN;BR-A-657K;
分子式：C27H31N7OS
分子量：501.646
精确质量：501.231
Psa：124.68
Logp：4.2212
编号系统
UNII：P58222188P
物化性质
密度：1.25g/cm3
安全信息
生产方法及用途
合成路线
-
参考文献
Kim, Tae Woo; Yoo, Byoung Wook; Lee, Joon Kwang; Kim, Ji Han; Lee, Kyung-Tae; Chi, Yong Ha; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1649 - 1654
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
