trans-4-Hydroxycrotonic acid (T-HCA), also known as γ-hydroxycrotonic acid (GHC), is an agent used in scientific research to study the GHB receptor. It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, where it acts as an agonist, but does not bind to the low-affinity GHB binding site, the GABAB receptor. Because of this, T-HCA does not produce sedation, and instead causes convulsions, which are thought to be caused by GHB receptor activation-evoked increases in extracellular glutamate concentrations, with one notable area where this occurs being the hippocampus.

CAS：24587-49-3
中文别名：
英文别名：4-HYDROXY-BUT-2-ENOIC ACID;
分子式：C4H6O3
分子量：102.089
精确质量：102.032
Psa：57.53
Logp：-0.3805

MDL号：MFCD00673880

沸点：338.7ºC at 760 mmHg
闪点：172.9ºC
蒸汽压：6.49E-06mmHg at 25°C

海关编码：2918199090