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化合物简介
L-2-amino-4-phosphonobutyric acid (or L-AP4) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors, but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.
基本信息
CAS:23052-81-5
中文别名:
英文别名:L-AP-4 L-AP4;L-AP4;L-AP-4,L-AP4;
分子式:C4H10NO5P
分子量:183.1
精确质量:183.03
Psa:130.66
Logp:-0.3336
中文别名:
英文别名:L-AP-4 L-AP4;L-AP4;L-AP-4,L-AP4;
分子式:C4H10NO5P
分子量:183.1
精确质量:183.03
Psa:130.66
Logp:-0.3336
编号系统
MDL号:MFCD00083244
PubChem号:24891296
PubChem号:24891296
物化性质
密度:1.628g/cm3
沸点:491.7ºC at 760mmHg
熔点:207-215 °C
闪点:251.2ºC
折射率:1.545
储存条件:0-6ºC
蒸汽压:5.18E-11mmHg at 25°C
沸点:491.7ºC at 760mmHg
熔点:207-215 °C
闪点:251.2ºC
折射率:1.545
储存条件:0-6ºC
蒸汽压:5.18E-11mmHg at 25°C
安全信息
安全说明:S26-S36
WGK Germany:3
危险类别码:R36/37/38
海关编码:2931900090
危险品标志:Xi
WGK Germany:3
危险类别码:R36/37/38
海关编码:2931900090
危险品标志:Xi
生产方法及用途
合成路线
-
参考文献
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), , vol. 41, # 2 p. 397 - 402,311 - 315
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