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化合物简介
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971 after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available. It is classed as a non-steroidal anti-inflammatory drug (NSAID) and is available in 250mg and 500mg tablets.
基本信息
CAS:22494-42-4
中文别名:5-(2,4-二氟苯基)水杨酸;二氟苯水杨酸;氟苯水杨酸;2\',4\'-二氟-4-羟基-[1,1\'-联苯]-3-羧酸;
英文别名:4\',6\'-difluoro-4-hydroxybiphenyl-3-carboxylic acid;5-(2,4-Difluorophenyl)salicylic acid;2-hydroxy-5-(2\',4\'-difluorophenyl)benzoic acid;Dolobis;Dolobid;Flustar;Diflunisalum;5-(2,4-difluorophenyl)-2-hydroxybenzoic acid;Flovacil;Adomal;Fluniget;Fluodonil;2\',4\'-difluoro-4-hydroxy-3-biphenylcarboxylic acid;2\',4\'-difluoro-4-hydroxy-[1,1\'-biphenyl]-3-carboxylic acid;
分子式:C13H8F2O3
分子量:250.198
精确质量:250.044
Psa:57.53
Logp:3.0356
中文别名:5-(2,4-二氟苯基)水杨酸;二氟苯水杨酸;氟苯水杨酸;2\',4\'-二氟-4-羟基-[1,1\'-联苯]-3-羧酸;
英文别名:4\',6\'-difluoro-4-hydroxybiphenyl-3-carboxylic acid;5-(2,4-Difluorophenyl)salicylic acid;2-hydroxy-5-(2\',4\'-difluorophenyl)benzoic acid;Dolobis;Dolobid;Flustar;Diflunisalum;5-(2,4-difluorophenyl)-2-hydroxybenzoic acid;Flovacil;Adomal;Fluniget;Fluodonil;2\',4\'-difluoro-4-hydroxy-3-biphenylcarboxylic acid;2\',4\'-difluoro-4-hydroxy-[1,1\'-biphenyl]-3-carboxylic acid;
分子式:C13H8F2O3
分子量:250.198
精确质量:250.044
Psa:57.53
Logp:3.0356
编号系统
MDL号:MFCD00057834
EINECS号:245-034-9
RTECS号:DV2030000
EINECS号:245-034-9
RTECS号:DV2030000
物化性质
外观与性状:白色固体
密度:1.437g/cm3
沸点:249 °C (15 mmHg)
熔点:32-36 °C
闪点:33 °C
折射率:1.601
稳定性:Stable at normal temperatures and pressures.
储存条件:Keep tightly closed. Store in a cool dry place.
蒸汽压:2.75E-07mmHg at 25°C
密度:1.437g/cm3
沸点:249 °C (15 mmHg)
熔点:32-36 °C
闪点:33 °C
折射率:1.601
稳定性:Stable at normal temperatures and pressures.
储存条件:Keep tightly closed. Store in a cool dry place.
蒸汽压:2.75E-07mmHg at 25°C
安全信息
RTECS号:DV2030000
安全说明:S22-S26-S36
危险类别码:R22; R36/37/38; R63
WGK Germany:3
海关编码:2918290000
危险品标志:Xn
安全说明:S22-S26-S36
危险类别码:R22; R36/37/38; R63
WGK Germany:3
海关编码:2918290000
危险品标志:Xn
生产方法及用途
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图谱
13C NMR : Predict

1H NMR : Predict

Mass spectrum (electron ionization)
