Tigecycline (INN) is an antibiotic used to treat a number of bacterial infections. It is a first in class glycylcycline that is administered intravenously. It was developed in response to the growing rate of Antibiotic resistance in bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include Gram-positive and Gram-negative organisms, including those of multi-drug resistance. It is approved to treat complicated skin and soft tissue infections (cSSTI), complicated intra-abdominal infections (cIAI), and community-acquired bacterial pneumonia (CAP) in individuals 18 years and older.

CAS：220620-09-7
中文别名：
英文别名：Tegecycline;9-t-Butylglycylamido-minocycline hydrate;Tygacil;Tigercycline;TIGECYCLINE GLYCYLCYCLINE;Glycylcycline;2-NAPHTHACENECARBOXAMIDE;WAY-GAR 936;TIGECYCLINE POWDER;Tigecycline;
分子式：C29H39N5O8
分子量：585.649
精确质量：585.28
Psa：205.76
Logp：1.6774

UNII：70JE2N95KR

密度：1.455 g/cm3
沸点：890.922ºC at 760 mmHg
闪点：492.612ºC
折射率：1.675
蒸汽压：0mmHg at 25°C

安全说明：S24/25
WGK Germany：3
海关编码：3004909090

用途
替加环素是一种新型的广谱活性的静脉注射用抗生素，对有抗药性的耐甲氧西林金黄色葡萄球菌也有活性，是甘氨酰四环素类中的首个药品。