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1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇
1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol
化合物简介
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. Bazedoxfiene is the result of an exclusive research collaboration between Wyeth Pharmaceuticals and Ligand Pharmaceuticals.
基本信息
CAS：198481-32-2
中文别名：巴多昔芬;
英文别名：TSE-424;bazedoxifene;Conbriza;Bazedoxifeno;
分子式：C30H34N2O3
分子量：470.603
精确质量：470.257
Psa：57.86
Logp：6.2689
中文别名：巴多昔芬;
英文别名：TSE-424;bazedoxifene;Conbriza;Bazedoxifeno;
分子式：C30H34N2O3
分子量：470.603
精确质量：470.257
Psa：57.86
Logp：6.2689
编号系统
UNII：Q16TT9C5BK
物化性质
密度：1.19g/cm3
沸点：694.4ºC at 760 mmHg
闪点：373.8ºC
折射率：1.622
蒸汽压：6.33E-20mmHg at 25°C
沸点：694.4ºC at 760 mmHg
闪点：373.8ºC
折射率：1.622
蒸汽压：6.33E-20mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
