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5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate
化合物简介
基本信息
CAS：194928-63-7
中文别名：
英文别名：8-[2,6-dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy)quinoline;5-((E)-2-{[({2,4-Dichloro-3-[2-methyl-4-(pyridin-2-ylmethoxy)-quinolin-8-yloxymethyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-vinyl)-pyridine-2-carboxylic acid ethyl ester;8-[2,6-dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methyl-4-(pyridin-2-ylmethoxy)quinoline;
分子式：C37H33Cl2N5O6
分子量：714.594
精确质量：713.181
Psa：132.84
Logp：7.158
中文别名：
英文别名：8-[2,6-dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy)quinoline;5-((E)-2-{[({2,4-Dichloro-3-[2-methyl-4-(pyridin-2-ylmethoxy)-quinolin-8-yloxymethyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-vinyl)-pyridine-2-carboxylic acid ethyl ester;8-[2,6-dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methyl-4-(pyridin-2-ylmethoxy)quinoline;
分子式：C37H33Cl2N5O6
分子量：714.594
精确质量：713.181
Psa：132.84
Logp：7.158
编号系统
物化性质
安全信息
生产方法及用途
合成路线
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参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Hatori, Chie; Aramori, Ichiro; Oku, Teruo; Tanaka, Hirokazu Journal of Medicinal Chemistry, 2004, vol. 47, # 11 p. 2853 - 2863 doi: 10.1021/jm030468n
