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化合物简介
Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patient's vitamin D status. At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days.
基本信息
CAS:19356-17-3
中文别名:25-羟基维生素D3;骨化三醇;
英文别名:25-Hydroxycholecalciferol;Calcidiol,Didrogyl,Hidroferol;Calcifediol;Vitamin D3 25 Calcifediol;Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol;25-Hydroxyvitamin D3;
分子式:C27H44O2
分子量:400.637
精确质量:400.334
Psa:40.46
Logp:6.7339
中文别名:25-羟基维生素D3;骨化三醇;
英文别名:25-Hydroxycholecalciferol;Calcidiol,Didrogyl,Hidroferol;Calcifediol;Vitamin D3 25 Calcifediol;Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol;25-Hydroxyvitamin D3;
分子式:C27H44O2
分子量:400.637
精确质量:400.334
Psa:40.46
Logp:6.7339
编号系统
MDL号:MFCD00867077
PubChem号:24895612
EINECS号:242-990-9
PubChem号:24895612
EINECS号:242-990-9
物化性质
密度:1.01 g/cm3
沸点:529.2ºC at 760 mmHg
闪点:221.4ºC
储存条件:-20ºC
沸点:529.2ºC at 760 mmHg
闪点:221.4ºC
储存条件:-20ºC
安全信息
安全说明:28-36/37-45
WGK Germany:3
危险类别码:R28
危险品运输编码:UN 2811 6
危险品标志:T+
危险标志:GHS02, GHS07
危险性描述:H225; H319
危险性防范说明:P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
信号词:Danger
WGK Germany:3
危险类别码:R28
危险品运输编码:UN 2811 6
危险品标志:T+
危险标志:GHS02, GHS07
危险性描述:H225; H319
危险性防范说明:P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
信号词:Danger
生产方法及用途
合成路线
-
参考文献
Andrews; Barton; Hesse; Pechet Journal of Organic Chemistry, 1986 , vol. 51, # 25 p. 4819 - 4828
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图谱
Predict 1H proton NMR
