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化合物简介
Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant controversy regarding safety and research fraud, the US Food and Drug Administration sharply curtailed the approved uses of the drug in 2007.
基本信息
CAS:191114-48-4
中文别名:红霉酮(特利霉素);
英文别名:KETEK;(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone;
分子式:C43H65N5O10
分子量:812.004
精确质量:811.473
Psa:171.85
Logp:4.8671
中文别名:红霉酮(特利霉素);
英文别名:KETEK;(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone;
分子式:C43H65N5O10
分子量:812.004
精确质量:811.473
Psa:171.85
Logp:4.8671
编号系统
UNII:KI8H7H19WL
物化性质
密度:1.26 g/cm3
沸点:966.2ºC at 760 mmHg
熔点:176-188ºC
闪点:538.2ºC
蒸汽压:0mmHg at 25°C
沸点:966.2ºC at 760 mmHg
熔点:176-188ºC
闪点:538.2ºC
蒸汽压:0mmHg at 25°C
安全信息
安全说明:S26; S36
危险类别码:R36/37/38
危险品标志:Xi
危险类别码:R36/37/38
危险品标志:Xi
生产方法及用途
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR
