Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. It is a human TAAR1 agonist.

CAS：19036-73-8
中文别名：
英文别名：dexnorfenfluramine;Dexibuprofen Lysine;d-norfenfluramine;
分子式：C10H12F3N
分子量：203.204
精确质量：203.092
Psa：26.02
Logp：3.2954

UNII：CLX07A6ZIY

密度：1.152g/cm3
沸点：215.2ºC at 760mmHg
闪点：88.9ºC
折射率：1.467
蒸汽压：0.15mmHg at 25°C

海关编码：2921499090