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化合物简介
Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene is a highly effective agent for prevention of mammary cancer induced in the rat by the carcinogen nitrosomethylurea and is significantly more potent than raloxifene in this regard. Arzoxifene is devoid of the uterotrophic effects of tamoxifen, suggesting that, in contrast to tamoxifen, it is unlikely that the clinical use of arzoxifene will increase the risk of developing endometrial carcinoma.
基本信息
CAS：182133-25-1
中文别名：2-(4-甲氧基苯基)-3-[4-[2-(1-哌啶基)乙氧基]苯氧基]-苯并[b]噻吩-6-醇;
英文别名：Arzoxifene;UNII-E569WG6E60;
分子式：C28H29NO4S
分子量：475.599
精确质量：475.182
Psa：79.4
Logp：6.8774
中文别名：2-(4-甲氧基苯基)-3-[4-[2-(1-哌啶基)乙氧基]苯氧基]-苯并[b]噻吩-6-醇;
英文别名：Arzoxifene;UNII-E569WG6E60;
分子式：C28H29NO4S
分子量：475.599
精确质量：475.182
Psa：79.4
Logp：6.8774
编号系统
UNII：E569WG6E60
物化性质
密度：1.234g/cm3
沸点：656.4ºC at 760mmHg
闪点：350.8ºC
折射率：1.635
蒸汽压：7.85E-18mmHg at 25°C
沸点：656.4ºC at 760mmHg
闪点：350.8ºC
折射率：1.635
蒸汽压：7.85E-18mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
