7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder. In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles (or as a vesicular glutamate reuptake inhibitor), an action that it mediates via competitive blockade of vesicular glutamate transporters (Ki = 0.59 mM).

CAS：18000-24-3
中文别名：
英文别名：7-Chlorokynurenic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-Cl-KYNA;7-chloro-4-hydroxyquinoline-2-carboxylic acid;7-chloro-4-hydroxy-2-carboxyquinoline;
分子式：C10H6ClNO3
分子量：223.613
精确质量：223.004
Psa：70.42
Logp：2.292

EINECS号：241-913-6

外观与性状：白色至淡黄色粉末
密度：1.549 g/cm3
沸点：395ºC at 760 mmHg
闪点：192.7ºC
折射率：1.648
蒸汽压：6E-07mmHg at 25°C

安全说明：S26-S36
危险类别码：R36/37/38
WGK Germany：3
海关编码：2933499090
危险品标志：Xi