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化合物简介
3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).
基本信息
CAS:161957-56-8
中文别名:2-氟-3-溴苯甲酸;
英文别名:2-fluoro-3-bromobenzoic acid;3-Bromo-2-Fluorobenzoic acid;3-Bromo-2-fluoro-benzoic acid;
分子式:C7H4BrFO2
分子量:219.008
精确质量:217.938
Psa:37.3
Logp:2.2864
中文别名:2-氟-3-溴苯甲酸;
英文别名:2-fluoro-3-bromobenzoic acid;3-Bromo-2-Fluorobenzoic acid;3-Bromo-2-fluoro-benzoic acid;
分子式:C7H4BrFO2
分子量:219.008
精确质量:217.938
Psa:37.3
Logp:2.2864
编号系统
MDL号:MFCD00665763
物化性质
熔点:168 °C
安全信息
海关编码:2916399090
危险品标志:Xi
危险品标志:Xi
生产方法及用途
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图谱
Predict 1H proton NMR

13C NMR : Predict

1H NMR : Predict
