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dimethyl((2S,2’S)-((2S,2’S)-2,2’-(5,5’-((S)-6-(2-cyclopropylthiazol-5-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3methyl-1oxobutane-2,1-diyl))dicarbamate
化合物简介
基本信息
CAS：1613081-64-3
中文别名：
英文别名：dimethyl N,N′-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{1H-imidazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate;
分子式：C49H55FN10O7S
分子量：947.087
精确质量：946.396
Psa：229.93
Logp：9.2466
中文别名：
英文别名：dimethyl N,N′-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{1H-imidazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate;
分子式：C49H55FN10O7S
分子量：947.087
精确质量：946.396
Psa：229.93
Logp：9.2466
编号系统
物化性质
安全信息
生产方法及用途
合成路线
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参考文献
Tong, Ling; Yu, Wensheng; Chen, Lei; Selyutin, Oleg; Dwyer, Michael P.; Nair, Anilkumar G.; Mazzola, Robert; Kim, Jae-Hun; Sha, Deyou; Yin, Jingjun; Ruck, Rebecca T.; Davies, Ian W.; Hu, Bin; Zhong, Bin; Hao, Jinglai; Ji, Tao; Zan, Shuai; Liu, Rong; Agrawal, Sony; Xia, Ellen; Curry, Stephanie; McMonagle, Patricia; Bystol, Karin; Lahser, Frederick; Carr, Donna; Rokosz, Laura; Ingravallo, Paul; Chen, Shiying; Feng, Kung-I; Cartwright, Mark; Asante-Appiah, Ernest; Kozlowski, Joseph A. Journal of Medicinal Chemistry, 2017, vol. 60, # 1 p. 290 - 306 doi: 10.1021/acs.jmedchem.6b01310
