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化合物简介

Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV). Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs.

基本信息

CAS:159989-64-7
中文别名:娜芙维亚;2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺;
英文别名:AG1343;Viracept (TN);UNII-HO3OGH5D7I;(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;[3H]-Nelfinavir;Nelfinavir Monomethane Sulfonate;[3S-(3R*,4AR*,8AR*,2\'S*,3\'S*)]-2-[2\'-Hydroxy-3\'-phenylthiomethyl-4\'-aza-5\'-oxo-5\'-(2\'\'-methyl-3\'\'-hydroxyphenyl)pentyl]decahydroisoquinoline-3-N-t-butylcarboxamide;(3S,4AS,8AS)-2-[(2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzoylamino)-4-phenylthiobutyl]decahydroisoquinoline-3-carboxylic acid t-butylamide;[14C]-Nelfinavir;Viracept;VRX496;Nelfinavir (INN);1ohr;
分子式:C33H49N3O7S2
分子量:663.888
精确质量:663.301
Psa:189.95
Logp:6.0521

编号系统

UNII:HO3OGH5D7I

物化性质

外观与性状:白色至灰白色结晶粉末
密度:1.22g/cm3
沸点:786.8ºC at 760 mmHg
闪点:429.7ºC
折射率:1.618
蒸汽压:4.38E-26mmHg at 25°C

安全信息

生产方法及用途

合成路线

上游原料

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图谱

Predict 1H proton NMR


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