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化合物简介
Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood–brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawal. It is currently only Food and Drug Administration approved for the treatment of postoperative ileus which it received in May 2008.
基本信息
CAS:156053-89-3
中文别名:2-([(2S)-2-([(3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基]甲基)-3-苯基丙酰]氨基)乙酸;
英文别名:Unii-Q153V49p3z;
分子式:C25H32N2O4
分子量:424.533
精确质量:424.236
Psa:89.87
Logp:3.3802
中文别名:2-([(2S)-2-([(3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基]甲基)-3-苯基丙酰]氨基)乙酸;
英文别名:Unii-Q153V49p3z;
分子式:C25H32N2O4
分子量:424.533
精确质量:424.236
Psa:89.87
Logp:3.3802
编号系统
MDL号:MFCD25970564
物化性质
密度:1.166g/cm3
沸点:684.1ºC at 760mmHg
熔点:210-213ºC
闪点:367.5ºC
沸点:684.1ºC at 760mmHg
熔点:210-213ºC
闪点:367.5ºC
安全信息
海关编码:2933399090
危险性防范说明:P273; P280; P305 + P351 + P338; P337 + P313; P391
危险标志:GHS07, GHS09
信号词:Warning
危险性描述:H315; H319; H400
危险性防范说明:P273; P280; P305 + P351 + P338; P337 + P313; P391
危险标志:GHS07, GHS09
信号词:Warning
危险性描述:H315; H319; H400
生产方法及用途
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上游原料
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图谱
Predict 1H proton NMR

13C NMR : Predict

1H NMR : Predict
