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化合物简介

Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood–brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawal. It is currently only Food and Drug Administration approved for the treatment of postoperative ileus which it received in May 2008.

基本信息

CAS:156053-89-3
中文别名:2-([(2S)-2-([(3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基]甲基)-3-苯基丙酰]氨基)乙酸;
英文别名:Unii-Q153V49p3z;
分子式:C25H32N2O4
分子量:424.533
精确质量:424.236
Psa:89.87
Logp:3.3802

编号系统

MDL号:MFCD25970564

物化性质

密度:1.166g/cm3
沸点:684.1ºC at 760mmHg
熔点:210-213ºC
闪点:367.5ºC

安全信息

海关编码:2933399090
危险性防范说明:P273; P280; P305 + P351 + P338; P337 + P313; P391
危险标志:GHS07, GHS09
信号词:Warning
危险性描述:H315; H319; H400

生产方法及用途

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图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


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