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(1R,2S,3S)-8-(3-氟丙基)-3-(4-碘苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯
methyl (3S,4S,5R)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
化合物简介
Ioflupane (123I) is the International Nonproprietary Name of a phenyltropane compound which is a neuro-imaging radiopharmaceutical drug, used by nuclear medicine physicians for the diagnosis of Parkinson's disease and the differential diagnosis of Parkinson's disease over other disorders presenting similar symptoms. It is injected into a patient and viewed with a gamma camera in order to acquire SPECT images of the brain with particular respect to the striatum, a subcortical region of the basal ganglia. The drug is sold under the tradename DaTSCAN and is manufactured by GE Healthcare, formerly Amersham plc. It is not marketed outside of Europe and the United States.
基本信息
CAS:155797-99-2
中文别名:
英文别名:(123I)FP-Cit;FP-Cit;2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane;8-Azabicyclo(3.2.1)octane-2-carboxylic acid,8-(3-fluoropropyl)-3-(4-iodophenyl)-,methyl ester,(1R-(exo,exo));
分子式:C18H23FINO2
分子量:431.284
精确质量:431.076
Psa:29.54
Logp:3.6982
中文别名:
英文别名:(123I)FP-Cit;FP-Cit;2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane;8-Azabicyclo(3.2.1)octane-2-carboxylic acid,8-(3-fluoropropyl)-3-(4-iodophenyl)-,methyl ester,(1R-(exo,exo));
分子式:C18H23FINO2
分子量:431.284
精确质量:431.076
Psa:29.54
Logp:3.6982
编号系统
物化性质
外观与性状:无色或淡黄色晶体
密度:1.45g/cm3
沸点:446.7ºC at 760mmHg
闪点:224ºC
折射率:1.561
蒸汽压:3.57E-08mmHg at 25°C
密度:1.45g/cm3
沸点:446.7ºC at 760mmHg
闪点:224ºC
折射率:1.561
蒸汽压:3.57E-08mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
