2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-PO4 from glucose at the phosphoglucoisomerase level. In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labeled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.

CAS：154-17-6
中文别名：2-脱氧葡萄糖;2-去氧-D-葡萄糖;2-脱氧-D-葡萄糖;2-脱氧-D-葡糖;2-去氧-D-葡糖;
英文别名：D-arabino-Hexose, 2-deoxy-;2-Deoxy-D-glucose;2-Deoxy-D-arabino-hexose;2-deoxy-d-arabino-hexos;D-Arabino-2-deoxyhexose;
分子式：C6H12O5
分子量：164.156
精确质量：164.068
Psa：97.99
Logp：-2.3496

MDL号：MFCD00151328
RTECS号：MQ3325000
BRN号：1723331
EINECS号：205-823-0
PubChem号：24894205

外观与性状：白色粉末
密度：1.533 g/cm3
沸点：411ºC at 760 mmHg
熔点：146-147ºC
闪点：202.3ºC
稳定性：Stable under normal temperatures and pressures.
储存条件：0-6ºC
蒸汽压：1.8E-08mmHg at 25°C

RTECS号：MQ3325000
安全说明：S24/25
WGK Germany：3
危险类别码：R20/21/22
海关编码：2912491000
危险品标志：Xn

用途
为天然抗代谢物类抗生素，具有具有能够抑制感染、酵母发酵、致病菌及肿瘤细胞生长等多种生理药理效应。具有抗抗菌、抗癌、抗癫痫等作用，用于预防病原菌感染等，可防止HSV、HIV、SARS等及病源菌引起的传染病，在医药及化妆品等行业具有广泛的应用前景。