Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (Kb = 5 nM). It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated with stroke and head injuries but was ultimately never marketed. In clinical trials, licostinel did not produce phencyclidine-like psychotomimetic effects at the doses tested, though transient sedation, dizziness, and nausea were observed. In addition to its actions at the NMDA receptor, licostinel also acts as an antagonist of the AMPA and kainate receptors at high concentrations (Kb = 0.9 µM and 2.5 µM, respectively).

CAS：153504-81-5
中文别名：
英文别名：6,7-Dichloro-5-nitro-2,3-quinoxalinedione;Licostinel;5-Nitro-6,7-dichloro-2,3-quinoxalinedione;2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-5-nitro;5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione;ACEA-1021;1,4-dihydro-6,7-dichloro-5-nitroquinoxalin-2,3-dione;6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione;6,7-dichloro-1,4-dihydro-8-nitro-2,3-quinoxalinedione;
分子式：C8H3Cl2N3O4
分子量：276.033
精确质量：274.95
Psa：111.54
Logp：1.9546

UNII：3Z3037LJTC

密度：1.757g/cm3
折射率：1.647