SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.

CAS：152121-47-6
中文别名：4-[5-(4-氟苯基)-2-[4-(甲基磺酰基)苯基]-1H-咪唑-4-基]-吡啶;4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑;
英文别名：4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole;RWJ 64809;4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)-1H-imidazole;PB 203580;Pyridine,4-(5-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl);4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)imidazole;4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine;4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine;
分子式：C21H16FN3OS
分子量：377.435
精确质量：377.1
Psa：77.85
Logp：5.5479

MDL号：MFCD00922198

外观与性状：白色固体
密度：1.42 g/cm3
沸点：615.6ºC at 760 mmHg
熔点：249 - 250ºC
闪点：326.1ºC
折射率：1.714
蒸汽压：2E-14mmHg at 25°C

安全说明：26-39
危险类别码：R22; R41
海关编码：2818200000
危险品标志：Xn
危险性防范说明：P280; P305 + P351 + P338
信号词：Danger
危险标志：GHS05, GHS07
危险性描述：H302; H318