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  • 1-(乙氧基甲基)-6-(苯基甲基)-5-丙-2-基嘧啶-2,4-二酮

    emivirine

化合物简介

Emivirine (MKC-442) is a failed experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase inhibitor. While emivirine showed promising antiviral activity in vitro, it failed to show sufficient efficacy in human trials. However it is still notable as an early proof of concept, which led to the discovery of a number of related antiviral drugs.

基本信息

CAS:149950-60-7
中文别名
英文别名:I-EBU;1EtOMe6Bz5i-Pr-U;Emivirine;Emivirine [USAN:INN];[14C]-Emivirine;1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4(1H,3H)-dione;Mkc 442;Coactinon;1-ethoxymethyl-5-isopropyl-6-benzyluracil;6-benzyl-1-(ethoxymethyl)-5-isopropyl uracil;6-benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione;
分子式:C17H22N2O3
分子量:302.368
精确质量:302.163
Psa:64.09
Logp:2.2448

编号系统

UNII:X87G8IX72O

物化性质

储存条件:2-8°C,密封,干燥

安全信息

海关编码:2933990090

生产方法及用途

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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