Cytochalasin B, the name of which comes from the Greek cytos (cell) and chalasis (relaxation), is a cell-permeable mycotoxin. It was found that substoichimetric concentrations of cytochalasin B (CB) strongly inhibit network formation by actin filaments. Due to this, it is often used in cytological research. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with cytochalasin B. Cytochalasin B makes the cytoplasm of the oocytes more fluid and makes it possible to aspirate the nuclear genome of the oocyte within a small vesicle of plasma membrane into a micro-needle. Thereby, the oocyte genome is removed from the oocyte, while preventing rupture of the plasma membrane.

CAS：14930-96-2
中文别名：细胞松弛素 B;
英文别名：CYTOCHALASIN B;Cytochalasin B;
分子式：C29H37NO5
分子量：479.608
精确质量：479.267
Psa：95.86
Logp：3.8209

MDL号：MFCD00077704
EINECS号：239-000-2
RTECS号：RO0205000
BRN号：1096207
PubChem号：24892890

外观与性状：粉末
密度：1.2 g/cm3
沸点：740.6ºC at 760 mmHg
熔点：218-223ºC
闪点：401.7ºC
折射率：1.596
储存条件：-20ºC
蒸汽压：4.98E-23mmHg at 25°C

安全说明：28-36/37-45
危险类别码：R26/27/28; R63
危险品运输编码：UN 1544 6
危险类别：6.1(a)
危险品标志：T+