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化合物简介
(–)-2β-Carboisopropoxy-3β-(4-iodophenyl)tropane (RTI-4229-121, IPCIT) is a stimulant drug used in scientific research, which was developed in the early 1990s. RTI-121 is a phenyltropane based, highly selective dopamine reuptake inhibitor and is derived from methylecgonidine. RTI-121 is a potent and long-lasting stimulant, producing stimulant effects for more than 10 hours after a single dose in mice which would limit its potential uses in humans, as it might have significant abuse potential if used outside of a medical setting. However RTI-121 occupies the dopamine transporter more slowly than cocaine, and so might have lower abuse potential than cocaine itself.
基本信息
CAS:146145-21-3
中文别名:
英文别名:(–)-2β-Carboisopropoxy-3β-(4-iodophenyl)tropane;RTI-4229-121;IPCIT;isopropyl (1R,2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate;propan-2-yl (3S,4S,5R)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;
分子式:C18H24INO2
分子量:413.293
精确质量:413.085
Psa:29.54
Logp:3.747
中文别名:
英文别名:(–)-2β-Carboisopropoxy-3β-(4-iodophenyl)tropane;RTI-4229-121;IPCIT;isopropyl (1R,2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate;propan-2-yl (3S,4S,5R)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;
分子式:C18H24INO2
分子量:413.293
精确质量:413.085
Psa:29.54
Logp:3.747
编号系统
物化性质
密度:1.418g/cm3
沸点:426.9ºC at 760mmHg
闪点:212ºC
折射率:1.574
蒸汽压:1.71E-07mmHg at 25°C
沸点:426.9ºC at 760mmHg
闪点:212ºC
折射率:1.574
蒸汽压:1.71E-07mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
