Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

CAS：138112-76-2
中文别名：N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺;阿戈美拉汀(I型);N-[2-(7-甲氧基-1-萘基)乙基] 乙酰胺;N-[2-(7-甲氧基萘-1-基)乙基]乙酰胺;
英文别名：N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098;Unii-137R1N49ad;N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide;AGOMELATINE;Valdoxan;AGOMELATIN;N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide;
分子式：C15H17NO2
分子量：243.301
精确质量：243.126
Psa：38.33
Logp：2.9179

MDL号：MFCD00916659

外观与性状：白色固体
密度：1.109g/cm3
沸点：478.8ºC at 760 mmHg
熔点：107-109ºC
闪点：243.4ºC

海关编码：2924199090

用途
一种新型的抗抑郁药，为褪黑激素受体激动剂和5-羟色胺(5-HT)2C受体拮抗剂。