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化合物简介
HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the Cannabis sativa plant. It showed a great efficacy against oncogenic human cells. HU-331 does not cause arrest in cell cycle, cell apoptosis or caspase activation. HU-331 inhibits DNA topoisomerase II even at nanomolar concentrations, but has shown a negligible effect on the action of DNA topoisomerase I. The cannabinoid quinone HU-331 is a very specific inhibitor of topoisomerase II, compared with most known anticancer quinones. One of the main objectives of these studies is the development of a new quinone derived compound that produces anti-neoplastic activity while maintaining low toxicity at therapeutic doses.
基本信息
CAS：137252-25-6
中文别名：
英文别名：3-HYDROXY-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXENE-1-YL]-5-PENTYL-2,5-CYCLOHEXADIENE-1,4-DIONE;
分子式：C21H28O3
分子量：328.445
精确质量：328.204
Psa：54.37
Logp：5.0056
中文别名：
英文别名：3-HYDROXY-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXENE-1-YL]-5-PENTYL-2,5-CYCLOHEXADIENE-1,4-DIONE;
分子式：C21H28O3
分子量：328.445
精确质量：328.204
Psa：54.37
Logp：5.0056
编号系统
UNII：I7Q196L4AU
物化性质
密度：1.091g/cm3
沸点：456ºC at 760 mmHg
闪点：243.7ºC
折射率：1.546
蒸汽压：3.11E-10mmHg at 25°C
沸点：456ºC at 760 mmHg
闪点：243.7ºC
折射率：1.546
蒸汽压：3.11E-10mmHg at 25°C
安全信息
生产方法及用途
合成路线
-
参考文献
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM Patent: WO2005/67917 A1, 2005 ; Location in patent: Page/Page column 30; Fig.1A ; WO 2005/067917 A1
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
