Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitro catechol type inhibitor of enzyme catechol-O-methyl transferase (COMT).

CAS：134308-13-7
中文别名：甲磺酸达氟沙星.甲达沙星.甲磺酸丹诺沙星;(3,4-二羟基-5-硝基苯基)-(4-甲基苯基)甲酮;
英文别名：(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone;Tasmar;(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone;3,4-Dihydroxy-4\'-methyl-5-nitrobenzophenone;1-(3,4-dihydroxy-5-nitrophenyl)-1-(4-methylphenyl)methanone;UNII-CIF6334OLY;Tasmar (TN);Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl);4\'-methyl-3,4-dihydroxy-5-nitro-benzophenone;[14C]-Tolcapone;Ro 40-7592;
分子式：C14H11NO5
分子量：273.241
精确质量：273.064
Psa：103.35
Logp：3.0686

MDL号：MFCD00866569

密度：1.419g/cm3
沸点：485.6ºC at 760mmHg
熔点：126-128ºC
折射率：1.661
蒸汽压：4.72E-10mmHg at 25°C