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化合物简介
基本信息
CAS：1341224-83-6
中文别名：
英文别名：INCB 8761(PF-4136309);INCB8761(PF-4136309);(S)-N-[2-(3-{trans-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexylamino}pyrrolidin-1-yl)-2-oxoethyl]-3-(trifluoromethyl)benzamide;(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide;
分子式：C29H31F3N6O3
分子量：568.59
精确质量：568.241
Psa：120.34
Logp：4.0278
中文别名：
英文别名：INCB 8761(PF-4136309);INCB8761(PF-4136309);(S)-N-[2-(3-{trans-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexylamino}pyrrolidin-1-yl)-2-oxoethyl]-3-(trifluoromethyl)benzamide;(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide;
分子式：C29H31F3N6O3
分子量：568.59
精确质量：568.241
Psa：120.34
Logp：4.0278
编号系统
物化性质
外观与性状：米色或淡黄色固体
安全信息
生产方法及用途
合成路线
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参考文献
Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; Kong, Lingquan; Glenn, Joseph; Anand, Rajan; Meloni, David; Robinson; Shao, Lixin; Storace, Lou; Li, Mei; Hughes, Robert O.; Devraj, Rajesh; Morton, Philip A.; Rogier, D. Joseph; Covington, Maryanne; Scherle, Peggy; Diamond, Sharon; Emm, Tom; Yeleswaram, Swamy; Contel, Nancy; Vaddi, Kris; Newton, Robert; Hollis, Greg; Metcalf, Brian ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 12 p. 913 - 918
