(E,E)-二(2-羟基苄亚基)丙酮(2-HBA) 2-HBA CAS号131359-24-5分子式、结构式、MSDS、物化性质、用途-化学科研者一站式服务平台

化合物简介

(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.

基本信息

CAS：131359-24-5
中文别名：
英文别名：(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one;
分子式：C17H14O3
分子量：266.291
精确质量：266.094
Psa：57.53
Logp：3.3935