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化合物简介
Epipregnanolone, also known as 3β-Hydoxy-5β-pregnan-20-one or 3β,5β-tetrahydroprogesterone (3β,5β-THP), is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation.
基本信息
CAS：128-21-2
中文别名：
英文别名：3.β.-Hydroxy-5.β.-tetrahydroprogesterone;5B-pregnan-3B-ol-20-one crystalline;3alpha-hydroxy-5beta-pregnan-20-one;3beta-hydroxy-5beta-pregnan-20-one;Pregnan-20-one, 3-hydroxy-, (3β,5β)-;
分子式：C21H34O2
分子量：318.493
精确质量：318.256
Psa：37.3
Logp：4.5952
中文别名：
英文别名：3.β.-Hydroxy-5.β.-tetrahydroprogesterone;5B-pregnan-3B-ol-20-one crystalline;3alpha-hydroxy-5beta-pregnan-20-one;3beta-hydroxy-5beta-pregnan-20-one;Pregnan-20-one, 3-hydroxy-, (3β,5β)-;
分子式：C21H34O2
分子量：318.493
精确质量：318.256
Psa：37.3
Logp：4.5952
编号系统
UNII：3KQ00893OL
物化性质
密度：1.053 g/cm3
沸点：431.2ºC at 760 mmHg
闪点：183.9ºC
折射率：1.524
蒸汽压：3.05E-09mmHg at 25°C
沸点：431.2ºC at 760 mmHg
闪点：183.9ºC
折射率：1.524
蒸汽压：3.05E-09mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
