(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.

CAS：125971-94-0
中文别名：(4R,6R)-6-氰甲基-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯;(4R,6R)-6-氰甲基-2,2-二甲基-1,3-二氧己环-4-醋酸叔丁酯;(4R,6R)-2,2-二甲基-6-氰甲基-1,3-二氧六环-4-乙酸叔丁酯;6-氰甲基-2,2-二甲基-1,3-二氧戊环-乙酸叔丁酯;
英文别名：ATS-8;(4R,6R)-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester;tert-Butyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxolane-4-acetate;(4R-cis)-1,1-Dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate;tert-Butyl (4R,6R)-6-CyanoMethyl-2,2-diMethyl-1,3-dioxane-4-acetate;
分子式：C14H23NO4
分子量：269.337
精确质量：269.163
Psa：68.55
Logp：2.54208

EINECS号：603-105-5

外观与性状：白色至淡黄色晶体粉末
密度：1.016 g/cm3
沸点：364.1ºC at 760 mmHg
熔点：65-69°C(lit.)
闪点：159.2ºC
折射率：1.439
蒸汽压：1.73E-05mmHg at 25°C

安全说明：S24/25
WGK Germany：3
海关编码：2932999099

用途
用作药品阿伐他汀中间体