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化合物简介
Rivastigmine (sold under the trade name Exelon) is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting. The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions.
基本信息
CAS:123441-03-2
中文别名:利斯的明;N-乙基-N-甲基-氨基甲酸 3-[(S)-1-(二甲氨基)乙基]苯酯;
英文别名:N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate;Rivastigmine;
分子式:C18H28N2O8
分子量:400.424
精确质量:400.185
Psa:147.84
Logp:0.6371
中文别名:利斯的明;N-乙基-N-甲基-氨基甲酸 3-[(S)-1-(二甲氨基)乙基]苯酯;
英文别名:N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate;Rivastigmine;
分子式:C18H28N2O8
分子量:400.424
精确质量:400.185
Psa:147.84
Logp:0.6371
编号系统
UNII:PKI06M3IW0
物化性质
密度:1.038g/cm3
沸点:316.2ºC at 760mmHg
闪点:145ºC
折射率:1.518
蒸汽压:0.000416mmHg at 25°C
沸点:316.2ºC at 760mmHg
闪点:145ºC
折射率:1.518
蒸汽压:0.000416mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
