Cetrorelix acetate (INN, USAN, BAN) (trade name Cetrotide) is an injectable gonadotropin-releasing hormone (GnRH) antagonist. A synthetic decapeptide, it is used is used in assisted reproduction to inhibit premature luteinizing hormone surges The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, cetrorelix can be used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). It is administered as either multiple 0.25mg daily subcutaneous injections or as a single-dose 3mg subcutaneous injection. The duration of the 3mg single dose is four days; if hCG is not administered within four days, a daily 0.25mg dose is started and continued until hCG is administered.

CAS：120287-85-6
中文别名：醋酸西曲瑞克 CETRORELIXACETATE;
英文别名：AC-D-2-NAL-4-CHLORO-D-PHE-B-(3-PYRIDYL)-D-ALA-SER-TYR-D-CIT-LEU-ARG-PRO-D-ALA-NH2;CETRORELIX ACETATE(CETROTIDE);CETRIZINEDIHYDROCHLORIDE;Cetrorelixacetate;Cetrorelixum [inn-latin];CETRORELIX;Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2;N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2;Ac-DNal-DpCl-Phe-DPal-Ser-Tyr-DCit-Leu-Arg-Pro-D-Ala-NH2;Cetrorelix acetate;AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH;Unii-oon1hfz4ba;CETRORELIX ACID;Cetrorelixum;Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2;
分子式：C70H92ClN17O14
分子量：1431.04
精确质量：1429.67
Psa：495.67
Logp：5.9323

外观与性状：白色粉末
密度：1.42g/cm3
折射率：1.667