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1-[2-[二[4-(三氟甲基)苯基]甲氧基]乙基]-5,6-二氢-2H-吡啶-3-羧酸
1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
化合物简介
CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 µM), and hence indirect and non-selective GABA receptor full agonist. It was investigated as a potential anticonvulsant, anxiolytic, and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed.
基本信息
CAS：110283-79-9
中文别名：
英文别名：1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid;1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3-pyridine carboxylic acid;CI-966;1,2,5,6-tetrahydro-1-<2-methoxy>ethyl>-3-pyridinecarboxylic acid;3-Pyridinecarboxylicacid,1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro;Tocris-1296;
分子式：C23H21F6NO3
分子量：473.408
精确质量：473.143
Psa：49.77
Logp：5.4848
中文别名：
英文别名：1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid;1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3-pyridine carboxylic acid;CI-966;1,2,5,6-tetrahydro-1-<2-
分子式：C23H21F6NO3
分子量：473.408
精确质量：473.143
Psa：49.77
Logp：5.4848
编号系统
UNII：4HVE799MEJ
物化性质
密度：1.34g/cm3
沸点：514.1ºC at 760mmHg
闪点：264.7ºC
折射率：1.517
蒸汽压：2.16E-11mmHg at 25°C
沸点：514.1ºC at 760mmHg
闪点：264.7ºC
折射率：1.517
蒸汽压：2.16E-11mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
