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化合物简介

Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

基本信息

CAS:110078-46-1
中文别名:MOZOBIL PLERIXAFOR;
英文别名:Mozobil;Unii-S915p5499n;1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene;Sdz sid 791;
分子式:C28H54N8
分子量:502.782
精确质量:502.447
Psa:78.66
Logp:2.2644

编号系统

MDL号:MFCD05662218

物化性质

密度:0.962
沸点:657.5ºC at 760 mmHg
闪点:361.8ºC
蒸汽压:1.06E-34mmHg at 25°C

安全信息

海关编码:2933990090

生产方法及用途

合成路线

上游原料

下游产品

图谱

Predict 1H proton NMR


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