The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable. It was isolated originally in the mid-1980s from the chalky soil, or \"calichi pits\", located in Kerrville, Texas. The sample was collected by a scientist working for Lederle Labs. It is extremely toxic to all cells and, in 2000, a CD33 antigen-targeted immunoconjugate N-acetyl dimethyl hydrazide calicheamicin was developed and marketed as targeted therapy against the non-solid tumor cancer acute myeloid leukemia (AML). Calicheamicin γ1 and the related enediyne esperamicin are the two of the most potent antitumor agents known.

CAS：108212-75-5
中文别名：
英文别名：Calicheamicin γ1I;CALICHEAMICIN GAMMA(1)I;Calicheamicin Gamma1;.calicheamicin γ1;.calichaemicin γ1;calicheamicin γ1 I;calicheamicin gamma1(I);
分子式：C55H74IN3O21S4
分子量：1368.35
精确质量：1367.27
Psa：409.64
Logp：4.3695