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  • 4-氨基-3-苯基丁酸盐酸盐

    4-Amino-3-phenylbutyric acid hydrochloride

化合物简介

Phenibut (fenibut, phenybut; brand names Noofen and Citrocard), contracted from β-phenyl-γ-aminobutyric acid (β-phenyl-GABA), is a central depressant and analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), or a GABA analogue. The addition of a phenyl ring allows phenibut to cross the blood–brain barrier. Phenibut was developed in the Soviet Union in the 1960s, and has since been used there as a pharmaceutical drug to treat a wide range of ailments, including posttraumatic stress disorder, anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders, among other conditions. In some other parts of the world, phenibut is not approved for clinical use, and is instead sold as a nutritional supplement. It has been reported by some researchers to possess nootropic actions for its ability to improve neurological functions,[medical citation needed] but others have not observed these effects. It is generally accepted that phenibut has anxiolytic effects in both animal models and in humans.

基本信息

CAS:1078-21-3
中文别名:3’-氯苯丙酮;4-氨基-3-苯基丁酸;
英文别名:fenigama;PHENIBUT;pgaba;FENIBUT;phenigama;Benzenepropanoic acid, β-(aminomethyl)-;fenigam;Phenygam;phenylgam;Phenybut;phenigam;
分子式:C10H14ClNO2
分子量:215.677
精确质量:215.071
Psa:63.32
Logp:2.7059

编号系统

EINECS号:214-079-6

物化性质

熔点:194.0-202.0°C

安全信息

海关编码:2922499990
危险品标志:Xi

生产方法及用途

用途
菲尼布特用作抗抑郁药。

合成路线

上游原料

下游产品

图谱

1H NMR : Predict


13C NMR : Predict


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