化学科研者一站式服务平台
-
1-苯基-3-丙-2-烯基-1,2,4,5-四氢-3-苯并氮杂卓-7,8-二醇
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
化合物简介
SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.
基本信息
CAS：104422-04-0
中文别名：
英文别名：3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;3-allyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;3-Allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine;5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;3-allyl-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol;
分子式：C19H22BrNO2
分子量：376.287
精确质量：375.083
Psa：43.7
Logp：4.1698
中文别名：
英文别名：3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;3-allyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;3-Allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine;5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;3-allyl-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol;
分子式：C19H22BrNO2
分子量：376.287
精确质量：375.083
Psa：43.7
Logp：4.1698
编号系统
UNII：XA99M7XZR5
物化性质
密度：1.157g/cm3
沸点：470.4ºC at 760mmHg
闪点：245.5ºC
储存条件：2-8ºC
蒸汽压：1.8E-09mmHg at 25°C
沸点：470.4ºC at 760mmHg
闪点：245.5ºC
储存条件：2-8ºC
蒸汽压：1.8E-09mmHg at 25°C
安全信息
WGK Germany：3
海关编码：2933990090
海关编码：2933990090
生产方法及用途
合成路线
-
参考文献
Neumeyer, John L.; Baindur, Nandkishore; Niznik, Hyman B.; Guan, H. C.; Seeman, Philip Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3366 - 3371
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
