MERCK SHARP and; DOHME CORP.; LIU, Kun; STACHEL, Shawn J.; COBURN, Craig A.; STEELE, Thomas G.; SOLL, Richard; WU, Hao; PENG, Xuanjin; CAI, Yaxian; DU, Xiaoxing; LI, Jian Patent: WO2010/94242 A1, 2010 ; Location in patent: Example 1.1 ;