MERCK SHARP and DOHME CORP.; ADDEX PHARMA S.A.; LIVERTON, Nigel, J.; BOLEA, Christelle; CELANIRE, Sylvain; YUNFU, Luo Patent: WO2012/8999 A2, 2012 ; Location in patent: Page/Page column 56; 57 ; WO 2012/008999 A2