THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan J.; PATNAIK, Samarjit; HEILIG, Markus A.; SOUTHALL, Noel T.; ZHENG, Wei Patent: WO2011/137220 A1, 2011 ; Location in patent: Page/Page column 51-50 ; WO 2011/137220 A1