F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew Patent: WO2011/92272 A1, 2011 ; Location in patent: Page/Page column 43 ; WO 2011/092272 A1