VERTEX PHARMACEUTICALS INCORPORATED; YANG, Xiaoqing; HADIDA RUAH, Sara, S.; GROOTENHUIS, Peter, D.J.; VAN GOOR, Fredrick, F.; BOTFIELD, Martyn, C.; ZLOKARNIK, Gregor Patent: WO2010/108155 A1, 2010 ; Location in patent: Page/Page column 14-15; 35-36; 45 ; WO 2010/108155 A1