MERCK SHARP and DOHME CORP.; ROMEO, Eric Thomas; MACHACEK, Michelle, R.; TROTTER, Benjamin Wesley; MILLER, Thomas Allen; ANDRESEN, Brian Michael; ANTHONY, Neville John; TAOKA, Brandon, M.; LIU, Yuan Patent: WO2012/151137 A1, 2012 ; Location in patent: Page/Page column 54 ; WO 2012/151137 A1