VERTEX PHARMACEUTICALS INCORPORATED; BINCH, Hayley; FANNING, Lev, T.D.; BOTFIELD, Martyn; GROOTENHUIS, Peter, D.J.; VAN GOOR, Fredrick; NUMA, Mehdi, Michel Djamel Patent: WO2010/48564 A1, 2010 ; Location in patent: Page/Page column 49-50 ;