ACTELION PHARMACEUTICALS LTD; BUR, Daniel; CORMINBOEUF, Olivier; CREN, Sylvaine; GRISOSTOMI, Corinna; LEROY, Xavier; RICHARD-BILDSTEIN, Sylvia Patent: WO2010/143116 A1, 2010 ; Location in patent: Page/Page column 53-54 ; WO 2010/143116 A1