VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; KNEGTEL, Ronald, Marcellus, Alphonsus; O'DONNELL, Michael; REAPER, Philip, Michael Patent: WO2011/143419 A1, 2011 ; Location in patent: Page/Page column 44-45 ; WO 2011/143419 A1