AMGEN INC.; BO, Yunxin, Y.; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; SIEGMUND, Aaron, C.; TAMAYO, Nuria, A.; YANG, Kevin Patent: WO2010/108074 A2, 2010 ; Location in patent: Page/Page column 43-44 ; WO 2010/108074 A2