BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; DE LOMBAERT, Stephane; DINES, Jonathon, Alan; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng Patent: WO2012/58254 A1, 2012 ; Location in patent: Page/Page column 50 ; WO 2012/058254 A1