MERCK SHARP andamp; DOHME CORP.; CHUNG, John, Y., L.; ZHANG, Yanfeng; ARTINO, Laura; BAXTER, Jennifer; COTE, Aaron, S.; DESMOND, Donal; SCOTT, Jeremy; VAYNSHTEYN, Yekaterina Patent: WO2010/80971 A1, 2010 ; Location in patent: Page/Page column 20 ; WO 2010/080971 A1